bFGF and VEGF act synergistically to enhance endothelial cytoprotection through upregulation of decay-accelerating factor
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bFGF and VEGF synergistically enhance endothelial cytoprotection via decay-accelerating factor induction.
The complement-regulatory protein decay-accelerating factor (DAF) can be upregulated on endothelial cells (EC) by protein kinase C (PKC)-dependent and -independent pathways. We hypothesized that basic fibroblast growth factor (bFGF) might induce EC DAF expression, providing a cytoprotective mechanism for angiogenic neovessels against complement-mediated injury. Incubation of umbilical vein, aor...
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